DHONUKSHE, P., GRIGORIEV, I., FISCHER, R., TOMINAGA, M., ROBINSON, D.G., HAŠEK, Jiří, PACIOREK, T., PETRÁŠEK, Jan, SEIFERTOVÁ, Daniela, TEJOS, R., MEISEL, L.A., ZAŽÍMALOVÁ, Eva, GADELLA, T.W.J., STIERHOF, Y. D., UEDA, T., OIWA, K., AKHMANOVA, A., BROCK, R., SPANG, A., FRIML, J. Auxin transport inhibitors impair vesicle motility and actin cytoskeleton dynamics in diverse eukaryotes. Proceedings of the National Academy of Sciences of the United States of America. 2008, 105(11), 4489-4494. ISSN 0027-8424. E-ISSN 1091-6490

Many aspects of plant development depend on distribution of the plant signalling molecule auxin. Auxin transport inhibitors (ATIs) interfere with directional auxin transport but the molecular mechanism of ATIs action has remained largely elusive. By using real time live cell microscopy, here we show that ATIs inhibit multiple vesicle trafficking processes in plant, yeast and mammalian cells. We also show how a common eukaryotic process of actin-based vesicle motility fulfils a plant-specific physiological role