ÖZDEMIR, Zülal, YANG, M., KIM, G., BILDZIUKEVICH, Uladzimir, ŠAMAN, David, LI, X., YOON, J.-N., WIMMER, Zdeněk. Redox-responsive nanoparticles self-assembled from porphyrin-betulinic acid conjugates for chemo- and photodynamic therapy. Dyes and Pigments. 2021, 190(JUN), 109307. ISSN 0143-7208. E-ISSN 1873-3743

The redox-responsive nanoparticle (NanoP-ss-BA) is designed by linking the porphyrin derivative (P) to the naturally occurring betulinic acid (BA) through a disulphide bond. A GSH triggered disassembly of NanoP-ss-BA effectively promotes a singlet oxygen (1O2) production, but also releases lipophilic anticancer drug, BA in situ. Beside this, high phototoxicity of NanoP-ss-BA serves it as a good candidate for photodynamic therapy (PDT).