TRÁVNÍČEK, Z., MALOŇ, M., POPA, I., DOLEŽAL, Karel, STRNAD, Miroslav. Preparation and cytotoxic activity of nickel(II) complexes with 6-benzylaminopurine derivatives. Transition Metal Chemistry. 2002, 27(8), 918-923. ISSN 0340-4285. E-ISSN 1572-901X.

Nickel(II) complexes with 6-benzylaminopurine (BAP) derivatives, namely 6-(3-chlorobenzylamino) purine (HL1), 6-4-chlorobenzylamino) purine (HL2) and 6-(4-fluorobenzylamino) purine (HL3), have been prepared and characterized by elemental analyses, i.r., u.v.-v.i.s., ES+ and FAB+ mass spectroscopy, magnetic susceptibility and conductivity measurements, and by thermal analysis. The complexes are: [Ni(L-1(H2O)(2)Cl].H2O, [Ni(L-1)(H2O)(NO3)].H2O, [Ni(L-2)(H2O)(2)Cl], [Ni(L-2)(H2O)(2)(NO3)].H2O, [Ni(HL2)(H2O)Cl-2].EtOH and [Ni(L-3)(H2O)(2)Cl]. They have been tested in vitro for their possible cytotoxic activity against G-361 ( human malignant melanoma), HOS (human osteogenic sarcoma), K-562 (human chronic myelogenous leukemia) and MCF-7 ( human breast adenocarcinoma) cell lines.