WATERWORTH, W.M., KOZÁK, Jaroslav, PROVOST, C.M., BRAY, C.M., ANGELIS, Karel, WEST, C.E. DNA ligase 1 deficient plants display severe growth defects and delayed repair of both DNA single and double strand breaks. BMC Plant Biology. 2009, 9(art.no.79), 1-12. ISSN 1471-2229. E-ISSN 1471-2229

DNA ligase enzymes catalyse the joining of adjacent polynucleotides and as such play important roles in DNA replication and repair pathways. Eukaryotes possess multiple DNA ligases with distinct roles in DNA metabolism, with clear differences in the functions of DNA ligase orthologues between animals, yeast and plants. DNA ligase 1, present in all eukaryotes, plays critical roles in both DNA repair and replication and is indispensable for cell viability.