HABIBI, E., SEPEHRARA, A., ARABNOZARI, H., SHARIFIANJAZI, F., ENDERAMI, S. E., SARKER, S. D., HASSANNIA, H., NAHAR, Lutfun. Alkaloid-rich extract of jujube seed regenerate the antiproliferative effect of paclitaxel on paclitaxel-resistant MDA-MB-231 breast cancer cell line in 2D and 3D cultures. Journal of Agriculture and Food Research. 2024, 18(DEC), 101438. ISSN 2666-1543. E-ISSN 2666-1543

Cancer is the second leading cause of death globally, and among all types of cancer, triple-negative breast cancer (TNBC) has one of the worst prognoses. The repeated use of chemotherapeutic drugs often leads to drug resistance, complicating treatment outcomes. This study aimed to investigate the effect of jujube alkaloid-rich extract on drug sensitivity and its antitumor effects on paclitaxel-resistant MDA-MB-231 cells in vitro.